Tseng CY, Hwang KP, Lin KH, Chen HY, Lu CC, Chiang CH
           Department of Pediatrics, Kaohsiung Medical College, Taiwan.
           Taiwan Erh Ko I Hsueh Hui Tsa Chih 1999 May-Jun;40(3):161-5

        To evaluate the immunogenicity of measles- mumps- rubella (MMR)
        vaccination with Japanese encephalitis (JE) vaccine nonsimultaneously
        and simultaneously, 145 babies, aged 15 months were enrolled into two
        groups. Group A received MMR and JE vaccines nonsimultaneously at an
        interval of 6 weeks; group B received the vaccinations simultaneously.
        Antibody titers of MMR and JE were detected before and 8 weeks after
        vaccination. A total of 118 babies (61 in group A; 57 in group B)
        completed the study. In group A, mean increments of logarithmic
        geometric mean titers (GMTs) of MMR and JE were 4.51, 5.93, 4.07 and
        1.99; seroresponse rates were 100% (61/61), 77.05% (47/61), 96.72%
        (59/61) and 59.02% (36/61) respectively. In group B, mean increments of
        logarithmic GMTs of MMR and JE were 4.35, 5.37, 4.44 and 1.93;
        seroresponse rates were 98.25% (56/57), 77.19% (44/57), 98.25% (56/57)
        and 57.89% (33/57) respectively. There were no significant differences
        between these two groups. These results suggest that simultaneous and
        nonsimultaneous vaccination with MMR and JE vaccines were similar in
        immunogenicity.