Aihara H, Takasaki T, Toyosaki-Maeda T, Suzuki R, Okuno Y, Kurane I
           Department of Microbiology, Kinki University School of Medicine,
           Osaka-sayama, Japan.
           Viral Immunol 2000;13(2):179-86

        Mouse brain-derived inactivated Japanese encephalitis (JE) vaccine is
        the only currently internationally accepted vaccine against JE virus. We
        analyzed cellular and humoral immune responses to the JE vaccine in
        healthy adults in order to understand the protective immunity induced by
        this vaccine. Immunization with the JE vaccine induced T-cell activation
        in vivo, demonstrated by increase in the plasma levels of interleukin
        (IL)-2 and soluble CD8. JE virus-specific antibodies determined in
        radioimmunoprecipitation (RIP), hemagglutination inhibition (HI), and
        neutralization assays were also induced by immunization with the JE
        vaccine. JE virus-specific memory T cells were detected 60 days after
        immunization. These results suggest that protective immunity induced by
        the inactivated JE vaccine includes JE virus-specific T cells as well as
        antibodies with multiple biological activities.Comparison of immunogenicity of
        simultaneous and nonsimultaneous vaccination with MMR and JE vaccine
        among 15-month-old children.